diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Base Information

Chemical Name:diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate
CAS No.:1360110-27-5
Molecular Formula:C₂₀H₂₈NO₈P
Molecular Weight:441.418
Hs Code.:

Synonyms:diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Suppliers and Price of diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

There total 3 articles about diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1360110-25-3
diethyl [(6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-5,6-dihydro-2H-pyran-3-yl]phosphonate

: 67-64-1
acetone

: 1360110-27-5
diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Guidance literature:: With pyrrolidine; at 20 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1055/s-0031-1289629

Reference yield:

: 1360110-23-1
(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

: 1360110-27-5
diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; acetic acid / benzene / Reflux

2: pyrrolidine / 20 °C

With pyrrolidine; piperidine; acetic acid; In benzene; 1: Knoevenagel condensation / 2: Michael addition;
DOI:10.1055/s-0031-1289629

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1360110-27-5
diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; trifluoroacetic acid / dimethyl sulfoxide / 12 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 - 20 °C

3: piperidine; acetic acid / benzene / Reflux

4: pyrrolidine / 20 °C

With pyrrolidine; piperidine; dmap; (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; benzene; 1: Aldol reaction / 2: Michael addition / 3: Knoevenagel condensation / 4: Michael addition;
DOI:10.1055/s-0031-1289629