N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

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Chemical Name:N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide
CAS No.:1448689-07-3
Molecular Formula:C₂₂H₂₅N₅O₃
Molecular Weight:407.472
Hs Code.:

Synonyms:N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

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Chemical Property of N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

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Technology Process of N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

There total 4 articles about N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1448689-06-2
4-(6-((2-(acetylmethylamino)ethyl)methylamino)pyrazin-2-yloxy)boronic acid

: 1448689-07-3
N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1448692-34-9
C₁₀H₈BClN₂O₃

: 1448689-07-3
N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / dimethyl sulfoxide / 15 h / 120 °C

2: triethylamine / dichloromethane / 15 h / 20 °C

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 15 h / 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; cesium fluoride; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1448692-35-0
C₁₄H₁₉BN₄O₃

: 1448689-07-3
N-[2-({6-[4-(6-hydroxymethylpyridin-3-yl)phenoxy]pyrazin-2-yl}methylamino)ethyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 15 h / 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water;