1H-Imidazo[4,5-b]pyridine-2-methanol, -alpha--methyl- (9CI)

Base Information

• Chemical Name: 1H-Imidazo[4,5-b]pyridine-2-methanol, -alpha--methyl- (9CI)
• CAS No.: 250651-52-6
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.179
• Mol file: 250651-52-6.mol

Synonyms:1H-Imidazo[4,5-b]pyridine-2-methanol,a-methyl- (9CI)

Chemical Property of 1H-Imidazo[4,5-b]pyridine-2-methanol, -alpha--methyl- (9CI)

Chemical Property:

• PSA: 61.80000
• LogP: 1.01120

Purity/Quality:

a-methyl-3H-Imidazo[4,5-b]pyridine-2-methanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazo[4,5-b]pyridine-2-methanol, -alpha--methyl- (9CI)

There total 2 articles about 1H-Imidazo[4,5-b]pyridine-2-methanol, -alpha--methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3-Diaminopyridine (452-58-4) + ethyl 2-hydroxypropionate (97-64-3,2676-33-7) → 2-(1-hydroxyethyl)-1H-imidazo[4,5-b]pyridine (250651-52-6)

Guidance literature:

With lithium bromide; at 110 - 115 ℃; for 6h; Neat (no solvent);

DOI:10.1016/j.cclet.2009.11.034

Reference yield: 48.0%

2,3-Diaminopyridine (452-58-4) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) → 2-(1-hydroxyethyl)-1H-imidazo[4,5-b]pyridine (250651-52-6)

Guidance literature:

at 140 - 150 ℃; for 4h;

DOI:10.1002/jhet.5570420705

Reference yield:

2-(1-hydroxyethyl)-1H-imidazo[4,5-b]pyridine (250651-52-6) → 2-acetylimidazo[4,5-b]pyridine-4-phenyl-3-thiosemicarbazone

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / chromium trioxide / H₂O; acetic acid / 0.08 h / 100 - 106 °C

2: 22.5 percent / acetic acid / propan-1-ol / Heating

With chromium(VI) oxide; acetic acid; In propan-1-ol; water; acetic acid;

DOI:10.1002/jhet.5570420705

upstream raw materials:

2,3-Diaminopyridine

LACTIC ACID

ethyl 2-hydroxypropionate

Downstream raw materials:

2-acetylimidazo[4,5-b]pyridine

2-imidazo[4,5-b]pyridinecarboxylic acid

Refernces

• 1、 Mylonas, Stavros,Mamalis, Athanasios. "Synthesis and antitumor activity of new thiosemicarbazones of 2-acetylimidazo[4,5-b]pyridine". . p. 1273 - 1281. Retrieved 2007/10/03.