1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone

Base Information

• Chemical Name: 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone
• CAS No.: 1363821-31-1
• Molecular Formula: C₃₆H₃₈N₂O₈
• Molecular Weight: 626.706
• Mol file: 1363821-31-1.mol

Synonyms:1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone

Chemical Property of 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone

There total 3 articles about 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

levulinic acid (123-76-2) + 5'-O-(4,4'-dimethoxytrityl)-N1-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one (125258-59-5) → 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone (1363821-31-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1039/c2ob06966k

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone (1363821-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / 1,4-dioxane / 2 h / 20 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1039/c2ob06966k

Reference yield:

N1-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one (22003-31-2,129463-65-6) → 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone (1363821-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / 1,4-dioxane / 2 h / 20 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1039/c2ob06966k

upstream raw materials:

4,4'-dimethoxytrityl chloride

levulinic acid

5'-O-(4,4'-dimethoxytrityl)-N¹-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one

N¹-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one

Downstream raw materials:

C₄₉H₅₄N₅O₁₅P