6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

Base Information

Chemical Name:6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine
CAS No.:1188301-69-0
Molecular Formula:C₂₀H₂₃BrClF₃N₄OSi
Molecular Weight:535.867
Hs Code.:

Synonyms:6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

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Chemical Property of 6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

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Technology Process of 6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

There total 4 articles about 6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1188301-64-5
4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

: 1188301-69-0
6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

Guidance literature:: 4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -70 ℃; Inert atmosphere;

2-chloropyrimidine; In tetrahydrofuran; hexane; at -78 - -40 ℃;

With water; at -5 - 20 ℃;

Reference yield:

: 1188301-69-0
6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

: 7631-86-9,105269-70-3,1317-48-2,13778-37-5,14464-46-1,14808-60-7,14832-85-0,15468-32-3,17679-64-0,87347-84-0,92283-58-4,99439-28-8,15723-40-7
SiO₂

Guidance literature:

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1188301-69-0
6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 1.5 h / 0 - 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 30 h / 95 °C / Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 - -70 °C / Inert atmosphere

3.2: 0.75 h / -78 - -40 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;