4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

Base Information

Chemical Name:4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole
CAS No.:1188301-64-5
Molecular Formula:C₁₆H₁₉Br₂F₃N₂OSi
Molecular Weight:500.228
Hs Code.:

Synonyms:4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

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Chemical Property of 4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

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Technology Process of 4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

There total 2 articles about 4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 159590-01-9
2,4,5-tribromo-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-imidazole

: 1188301-64-5
4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 95 ℃; for 30h; Inert atmosphere;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1188301-64-5
4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 1.5 h / 0 - 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 30 h / 95 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;

Reference yield: 82.0%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1188301-64-5
4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole

: 1188301-69-0
6-(4-bromo-2-(4-(trifluoromethyl)phenyl)-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloro-1,6-dihydropyrimidine

Guidance literature:: 4,5-dibromo-2-(4-(trifluoromethyl)phenyl)-1-((2-trimethylsilyl)ethoxy)methyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -70 ℃; Inert atmosphere;

2-chloropyrimidine; In tetrahydrofuran; hexane; at -78 - -40 ℃;

With water; at -5 - 20 ℃;