N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

Base Information

Chemical Name:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide
CAS No.:1000334-14-4
Molecular Formula:C₂₅H₃₂N₂O₄
Molecular Weight:424.54
Hs Code.:

Synonyms:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

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Chemical Property of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

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Technology Process of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

There total 10 articles about N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1000334-09-7
N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride

: 128329-72-6
5-(phenylmethoxy)pentanoic acid chloride

: 1000334-14-4
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

Guidance literature:: With pyridine; at 0 ℃; for 0.25h;

Reference yield:

: 81945-13-3
4-bromo-7-hydroxy-2,3-dihydro-1H-inden-1-one

: 1000334-14-4
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; acetic anhydride / acetic acid / 3 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 40 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 0.5 h

4.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

5.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

8.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

9.1: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; nitric acid; acetic anhydride; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1000334-05-3
(6-amino-7-methoxy-2,3-dihydro-1H-inden-1-ylidene)acetonitrile

: 1000334-14-4
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-5-(benzyloxy)pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

4: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

5: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; boron tribromide; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane;