ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

Base Information

Chemical Name:ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate
CAS No.:871835-18-6
Molecular Formula:C₂₇H₂₅F₉N₆O₄
Molecular Weight:668.519
Hs Code.:

ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

Synonyms:ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

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Chemical Property of ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

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Technology Process of ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

There total 11 articles about ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 871834-60-5
4-[(3,5-bis-trifluoromethylphenyl)-(2H-tetrazol-5-yl)-methyl]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoxaline-1-carboxylic acid ethyl ester

: 96-32-2
bromoacetic acid methyl ester

: 871835-18-6
ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 60 ℃; for 1.5h;

Reference yield:

: 871834-51-4
2-(2-nitro-4-trifluoromethylphenylamino)-butan-1-ol

: 871835-18-6
ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / CH₂Cl₂

2: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

3: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

4: 74 percent / DIEA; DMP

5: pyridine / CH₂Cl₂

6: NaN₃; NH₄Cl / dimethylformamide / Heating

7: base

With pyridine; sodium azide; phthalic acid dimethyl ester; hydrogen; tetra-(n-butyl)ammonium iodide; ammonium chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: 871834-52-5
methanesulfonic acid 2-(2-nitro-4-trifluoromethylphenylamino)-butyl ester

: 871835-18-6
ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(2-methoxy-2-oxoethyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

2: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

3: 74 percent / DIEA; DMP

4: pyridine / CH₂Cl₂

5: NaN₃; NH₄Cl / dimethylformamide / Heating

6: base

With pyridine; sodium azide; phthalic acid dimethyl ester; hydrogen; tetra-(n-butyl)ammonium iodide; ammonium chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112