(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

Base Information

Chemical Name:(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester
CAS No.:1236324-26-7
Molecular Formula:C₃₈H₄₈N₄O₉
Molecular Weight:704.821
Hs Code.:

(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

Synonyms:(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

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Chemical Property of (2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

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Technology Process of (2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

There total 4 articles about (2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1236324-27-8
2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester

: 63628-63-7
Nε-benzyloxycarbonyl-L-lysine tert-butyl ester

: 1236324-26-7
(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

Guidance literature:: bis(trichloromethyl) carbonate; 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester; With 4-methyl-morpholine; In dichloromethane; at -10 ℃; for 1h;

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester; In dichloromethane; at -10 - 20 ℃; for 22h;

Reference yield:

: 155290-47-4
2-[2-(tert-butoxycarbonyl)hydrazinyl]benzoic acid

: 1236324-26-7
(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / water; methanol / pH 7

1.2: 4 h / 20 °C

2.1: 4-methyl-morpholine / dichloromethane / 1 h / -10 °C

2.2: 22 h / -10 - 20 °C

With 4-methyl-morpholine; caesium carbonate; In methanol; dichloromethane; water;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1236324-26-7
(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / 1,4-dioxane; water / 24 h / 0 - 20 °C / pH 8 - 9

2.1: caesium carbonate / water; methanol / pH 7

2.2: 4 h / 20 °C

3.1: 4-methyl-morpholine / dichloromethane / 1 h / -10 °C

3.2: 22 h / -10 - 20 °C

With 4-methyl-morpholine; sodium carbonate; caesium carbonate; In 1,4-dioxane; methanol; dichloromethane; water;