2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester

Base Information

• Chemical Name: 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester
• CAS No.: 1236324-27-8
• Molecular Formula: C₁₉H₂₂N₂O₄
• Molecular Weight: 342.395
• Mol file: 1236324-27-8.mol

Synonyms:2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester

Chemical Property of 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester

There total 3 articles about 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl bromide (100-39-0) + 2-[2-(tert-butoxycarbonyl)hydrazinyl]benzoic acid (155290-47-4) → 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester (1236324-27-8)

Guidance literature:

2-[2-(tert-butoxycarbonyl)hydrazinyl]benzoic acid; With caesium carbonate; In methanol; water; pH=7;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester (1236324-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / 1,4-dioxane; water / 24 h / 0 - 20 °C / pH 8 - 9

2.1: caesium carbonate / water; methanol / pH 7

2.2: 4 h / 20 °C

With sodium carbonate; caesium carbonate; In 1,4-dioxane; methanol; water;

Reference yield:

2-hydrazinobenzoic acid hydrochloride (33906-30-8,52356-01-1) → 2-[2-(tert-butoxycarbonyl)hydrazino]benzoic acid benzyl ester (1236324-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / 1,4-dioxane; water / 24 h / 0 - 20 °C / pH 8 - 9

2.1: caesium carbonate / water; methanol / pH 7

2.2: 4 h / 20 °C

With sodium carbonate; caesium carbonate; In 1,4-dioxane; methanol; water;

upstream raw materials:

benzyl bromide

2-[2-(tert-butoxycarbonyl)hydrazinyl]benzoic acid

di-tert-butyl dicarbonate

2-hydrazinobenzoic acid hydrochloride

Downstream raw materials:

(2S)-6-(benzyloxycarbonylamino)-2-[1-(2'-(benzyloxycarbonyl)phenyl)-2-(tert-butoxycarbonyl)hydrazinocarbonylamino]hexanoic acid tert-butyl ester