L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt

Base Information

• Chemical Name: L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt
• CAS No.: 96561-36-3
• Molecular Formula: C₉H₁₃NO*C₁₈H₁₃NO₇
• Molecular Weight: 506.512

Synonyms:L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt

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Chemical Property of L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt

There total 3 articles about L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) + 2-phthalimido-3-hydroxy-3-(3,4-methylenedioxyphenyl)propionic acid (1458647-14-7,96614-52-7) → L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt (96561-36-3)

Guidance literature:

In methanol; at 25 - 30 ℃; for 3h; Large scale;

Reference yield:

phthalimide (136918-14-4,85-41-6) → L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt (96561-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 2 h / -10 - 30 °C / Large scale

2.1: sodium carbonate / water / 15 - 35 °C / Large scale

2.2: 2.5 h / 15 - 25 °C / pH 1 - 2 / Large scale

3.1: methanol / 3 h / 25 - 30 °C / Large scale

With sodium carbonate; triethylamine; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

N-methoxycarbonylphthalimide (25543-10-6) → L-threo-(N-phthaloyl-3-(3,4-methylenedioxyphenyl)serine) norephedrine salt (96561-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / water / 15 - 35 °C / Large scale

1.2: 2.5 h / 15 - 25 °C / pH 1 - 2 / Large scale

2.1: methanol / 3 h / 25 - 30 °C / Large scale

With sodium carbonate; In methanol; water;

upstream raw materials:

phthalimide

N-methoxycarbonylphthalimide

(1R,2S)-norephedrine

2-phthalimido-3-hydroxy-3-(3,4-methylenedioxyphenyl)propionic acid

Downstream raw materials:

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-hydroxypropanoic acid