(2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Base Information

• Chemical Name: (2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine
• CAS No.: 1428339-77-8
• Molecular Formula: C₁₉H₁₇F₄NO₂
• Molecular Weight: 367.343
• Mol file: 1428339-77-8.mol

Synonyms:(2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Chemical Property of (2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

There total 1 articles about (2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-phenylpropanoyl)-oxazolidine → (2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine (1428339-77-8)

Guidance literature:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-phenylpropanoyl)-oxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 ℃; for 18h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo400210j

Reference yield:

(2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine (1428339-77-8) → C19H19F4NO2

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo400210j

Reference yield:

(2S,4R)-3-[(2R)-2-fluoro-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine (1428339-77-8) → (2S,4R)-3-[(R)-2-fluorohexanoyl]-4-phenyl-2-trifluoromethyloxazolidine (1428339-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / -10 °C / Inert atmosphere

2.1: acetic acid / chloroform / 2 h

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

4.2: 18 h / -78 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hexamethyldisilazane; acetic acid; In tetrahydrofuran; diethyl ether; chloroform;

DOI:10.1021/jo400210j

Downstream raw materials:

(2S,4R)-4-phenyl-3-phenylacetyl-2-trifluoromethyloxazolidine

(2S,4R)-hexanoyl-4-phenyl-2-trifluoromethyloxazolidine

(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

(2S,4R)-3-[(R)-2-fluorohexanoyl]-4-phenyl-2-trifluoromethyloxazolidine