(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

Base Information

Chemical Name:(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine
CAS No.:1428339-76-7
Molecular Formula:C₁₈H₁₅F₄NO₂
Molecular Weight:353.316
Hs Code.:

Synonyms:(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

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Chemical Property of (2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

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Technology Process of (2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

There total 11 articles about (2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1428339-73-4
(2S,4R)-4-phenyl-3-phenylacetyl-2-trifluoromethyloxazolidine

: 1428339-76-7
(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: (2S,4R)-4-phenyl-3-phenylacetyl-2-trifluoromethyloxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 ℃; for 18h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo400210j

Reference yield:

: (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-phenylpropanoyl)-oxazolidine

: 1428339-76-7
(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 18 h / -78 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 2 h / -10 °C / Inert atmosphere

3.1: acetic acid / chloroform / 2 h

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

5.2: 18 h / -78 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hexamethyldisilazane; acetic acid; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1021/jo400210j

Reference yield:

: C₁₉H₁₉F₄NO₂

: 1428339-76-7
(2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / chloroform / 2 h

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

3.2: 18 h / -78 °C / Inert atmosphere

With sodium hexamethyldisilazane; acetic acid; In tetrahydrofuran; chloroform;
DOI:10.1021/jo400210j