3-cyanobenzaldehyde diethyl acetal

Base Information

• Chemical Name: 3-cyanobenzaldehyde diethyl acetal
• CAS No.: 945981-95-3
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 945981-95-3.mol

Synonyms:3-cyanobenzaldehyde diethyl acetal

Chemical Property of 3-cyanobenzaldehyde diethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyanobenzaldehyde diethyl acetal

There total 2 articles about 3-cyanobenzaldehyde diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-Cyanobenzaldehyde (24964-64-5) + orthoformic acid triethyl ester (122-51-0) → 3-cyanobenzaldehyde diethyl acetal (945981-95-3)

Guidance literature:

hydrogenchloride; In ethanol; Heating;

DOI:10.1021/jm0611657

Reference yield: 81.0%

3-bromobenzaldehyde diethylacetal (75148-49-1) + potassium ferrocyanide → 3-cyanobenzaldehyde diethyl acetal (945981-95-3)

Guidance literature:

With dichloro[bis{1-(dicyclohexylphosphanyl)piperidine}]palladium; sodium carbonate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 8h; Inert atmosphere;

DOI:10.1002/chem.201102936

Reference yield: 98.0%

3-cyanobenzaldehyde diethyl acetal (945981-95-3) + trityl chloride (76-83-5) → 5-(3-diethoxymethylphenyl)-1-triphenylmethyl-1H-tetrazole (945981-72-6)

Guidance literature:

3-cyanobenzaldehyde diethyl acetal; With tributyltin azide; In toluene; Heating;

trityl chloride; With sodium hydroxide; In toluene; at 20 ℃; for 6h; Further stages.;

DOI:10.1021/jm0611657

upstream raw materials:

3-Cyanobenzaldehyde

orthoformic acid triethyl ester

3-bromobenzaldehyde diethylacetal

Downstream raw materials:

5-(3-diethoxymethylphenyl)-1-triphenylmethyl-1H-tetrazole

3-(1H-tetrazole-5-yl)benzaldehyde

Refernces

• 1、 Jütten, Peter,Schumann, Winfried,H?rtl, Albert,Dahse, Hans-Martin,Gr?fe, Udo. "Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase". . p. 3661 - 3666. Retrieved 2008/02/11.