C₄₅H₄₈N₆O₁₅S₃

Base Information

Chemical Name:C₄₅H₄₈N₆O₁₅S₃
CAS No.:1399690-58-4
Molecular Formula:C₄₅H₄₈N₆O₁₅S₃
Molecular Weight:1009.11
Hs Code.:

C<sub>45</sub>H<sub>48</sub>N<sub>6</sub>O<sub>15</sub>S<sub>3</sub>

Synonyms:C₄₅H₄₈N₆O₁₅S₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₄₅H₄₈N₆O₁₅S₃

Chemical Property:

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Technology Process of C₄₅H₄₈N₆O₁₅S₃

There total 6 articles about C₄₅H₄₈N₆O₁₅S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1399690-57-3
cyclo[Hse-Thr(Oxz)]3

: 98-59-9
p-toluenesulfonyl chloride

: 1399690-58-4
C₄₅H₄₈N₆O₁₅S₃

Guidance literature:: With trimethylamine hydrochloride; triethylamine; In acetonitrile; at 0 ℃; for 3h;
DOI:10.1080/10610278.2012.688128

Reference yield:

: 1399690-47-1
Boc-Hse(Bn)-Thr(Oxz)-OMe

: 1399690-58-4
C₄₅H₄₈N₆O₁₅S₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; sodium hydroxide / methanol / 2 h / 20 °C

1.2: pH 5

2.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C

3.1: dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

6.1: trimethylamine hydrochloride; triethylamine / acetonitrile / 3 h / 0 °C

With palladium 10% on activated carbon; water; hydrogen; trimethylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/10610278.2012.688128

Reference yield:

: 1399690-48-2
Boc-Hse(Bn)-Thr-OMe

: 1399690-58-4
C₄₅H₄₈N₆O₁₅S₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 7 h / -20 - 20 °C / Inert atmosphere

2.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 6 h / -20 - 20 °C

3.1: water; sodium hydroxide / methanol / 2 h / 20 °C

3.2: pH 5

4.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C

5.1: dichloromethane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C

7.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

8.1: trimethylamine hydrochloride; triethylamine / acetonitrile / 3 h / 0 °C

With Bromotrichloromethane; palladium 10% on activated carbon; water; hydrogen; trimethylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/10610278.2012.688128