1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea

Base Information

• Chemical Name: 1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea
• CAS No.: 132424-57-8
• Molecular Formula: C₁₆H₁₄ClN₃S₂
• Molecular Weight: 347.892

Synonyms:1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea

Chemical Property of 1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea

Chemical Property:

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Technology Process of 1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea

There total 2 articles about 1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene (4651-91-6) + 4-Chlorophenyl isothiocyanate (2131-55-7) → 1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea (132424-57-8)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; for 1h;

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea (132424-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / ethanol

2: 60 percent / powd. NaOH / dimethylformamide / 2 h / 20 °C

With sodium hydroxide; sulfur; diethylamine; In ethanol; N,N-dimethyl-formamide; 1: Cycloaddition / 2: Addition;

Reference yield: 79.0%

1-(4-Chloro-phenyl)-3-(3-cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-thiourea (132424-57-8) → 4-(4-Chloro-phenylamino)-5,6,7,8-tetrahydro-1H-benzo[4,5]thieno[2,3-d]pyrimidine-2-thione (132167-32-9)

Guidance literature:

In pyridine; for 3h; Heating;

upstream raw materials:

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene

4-Chlorophenyl isothiocyanate

cyclohexanone

Downstream raw materials:

4-(4-Chloro-phenylamino)-5,6,7,8-tetrahydro-1H-benzo[4,5]thieno[2,3-d]pyrimidine-2-thione

4-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydrobenzothieno<2,3-d>pyrimidine

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