132167-32-9Relevant academic research and scientific papers
Synthesis, Antitumor and Anti-HIV-1 Testing of Certain Thieno[2,3-d]pyrimidine, Thieno[2,3-d]imidazo[1,2-c] pyrimidine and Thieno[2,3-d][1,3]thiazine Derivatives
Shehata,El-Subbagh,Abdelal,El-Sherbeny,Al-Obaid
, p. 148 - 163 (2007/10/03)
A series of tetrahydrobenzo[b]thieno[2,3-d]pyrimidines, thieno[3,2-e]imidazo[1,2-c]pyrimidines and thieno[2,3-dt][1,3]thiazines was synthesized as antitumor, antiviral agents. Compounds 2, 3 and 17 possessed moderate Anti-HIV-1 potency with EC50 values ranging from 1.83 × 10-5 to 3.42 × 10-5 molar concentrations. All of the tested compounds showed cytotoxic effects (log GI50 ≤ -4.0) against the growth of a variety of human tumor cell lines, including those derived from solid tumors. Compounds 3 and 7 showed strong potency while compounds 11 and 16 exhibited moderate activity. The detailed synthesis, spectroscopic and biological data are reported.
