(Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

Base Information

Chemical Name:(Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid
CAS No.:168162-51-4
Molecular Formula:C₃₂H₂₄F₂N₂O₄
Molecular Weight:538.55
Hs Code.:

Synonyms:(Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

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Chemical Property of (Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

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Technology Process of (Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

There total 10 articles about (Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 168162-45-6
(Z)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

: 168162-51-4
(Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 7h;
DOI:10.1248/cpb.48.1644 DOI:10.1248/cpb.51.1075

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 168162-51-4
(Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 76 percent / aq. LiOH / methanol / 7 h / 20 °C

With pyridine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1248/cpb.48.1644 DOI:10.1248/cpb.51.1075

Reference yield:

: 24310-36-9
1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 168162-51-4
(Z)-{4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 78 percent / N-fluoro-benzenesulfonimide / tetrahydrofuran / 1 h / 0 °C

2.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: N-fluoropyridinium trifluoromethanesulfonate / CH₂Cl₂ / 2 h / Heating

4.1: H₂SO₄; AcOH / 14 h / 60 °C

5.1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

6.1: 83 percent / SnCl₂ / ethyl acetate / 5 h / Heating

7.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

7.2: 76 percent / tetrahydrofuran / 10 h / -78 - 0 °C

8.1: pyridine / CH₂Cl₂ / 1 h / 20 °C

9.1: 76 percent / aq. LiOH / methanol / 7 h / 20 °C

With pyridine; lithium hydroxide; sulfuric acid; sodium hydride; N-fluoropyridinium triflate; acetic acid; triethylamine; tin(ll) chloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.48.1644