1-Benzyl-4-benzyliminopiperidine

Base Information

• Chemical Name: 1-Benzyl-4-benzyliminopiperidine
• CAS No.: 119198-98-0
• Molecular Formula: C₁₉H₂₂N₂
• Molecular Weight: 278.397
• DSSTox Substance ID: DTXSID401344390
• Nikkaji Number: J998.124A
• Mol file: 119198-98-0.mol

Synonyms:1-benzyl-4-benzyliminopiperidine;N,1-Dibenzyl-4-piperidinimine;SCHEMBL9232557;XPQITDHWKMRSTP-UHFFFAOYSA-N;DTXSID401344390;119198-98-0

Chemical Property of 1-Benzyl-4-benzyliminopiperidine

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 278.178298710
• Heavy Atom Count: 21
• Complexity: 315

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCC1=NCC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 1-Benzyl-4-benzyliminopiperidine

There total 1 articles about 1-Benzyl-4-benzyliminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-phenylmethyl-4-piperidone (3612-20-2) + benzylamine (100-46-9) → N-(1-benzylpiperidin-4-ylidene)-1-phenylmethanamine (119198-98-0)

Guidance literature:

With potassium carbonate; In toluene; at 60 ℃; for 16h;

DOI:10.1021/jo802456w

Reference yield: 92.0%

N-(1-benzylpiperidin-4-ylidene)-1-phenylmethanamine (119198-98-0) + allylmagnesium bromide (1730-25-2) → 4-allyl-N,1-dibenzylpiperidin-4-amine (336108-92-0)

Guidance literature:

N-(1-benzylpiperidin-4-ylidene)-1-phenylmethanamine; allylmagnesium bromide; In toluene; at 0 - 20 ℃; for 16h;

With hydrogenchloride; water; In toluene; pH=1; Cooling with ice;

With potassium carbonate; In water; toluene; pH=12;

DOI:10.1021/jo802456w

Reference yield:

4-(chlorocarbonyl)pyridine (14254-57-0) + N-(1-benzylpiperidin-4-ylidene)-1-phenylmethanamine (119198-98-0) → N-benzyl-N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)isonicotinamide (1429043-79-7)

Guidance literature:

4-(chlorocarbonyl)pyridine; With triethylamine; In dichloromethane; at 0 ℃; for 0.0333333h; Inert atmosphere; Molecular sieve;

N-(1-benzylpiperidin-4-ylidene)-1-phenylmethanamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol400571j

upstream raw materials:

1-phenylmethyl-4-piperidone

benzylamine

Downstream raw materials:

4-allyl-N,1-dibenzylpiperidin-4-amine

1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one

N-benzyl-N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)isonicotinamide