1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one

Base Information

• Chemical Name: 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one
• CAS No.: 1429043-93-5
• Molecular Formula: C₂₆H₂₄F₃N₃O₃S
• Molecular Weight: 515.556
• Mol file: 1429043-93-5.mol

Synonyms:1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one

Chemical Property of 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one

There total 5 articles about 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

trifluoromethylsulfonic anhydride (358-23-6) + N-benzyl-N-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)isonicotinamide (1429043-79-7) → 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one (1429043-93-5)

Guidance literature:

In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol400571j

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one (1429043-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.03 h / 0 °C / Inert atmosphere; Molecular sieve

2.2: 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 0 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/ol400571j

Reference yield:

benzylamine (100-46-9) → 1',5'-dibenzyl-1-((trifluoromethyl)sulfonyl)-3a',4',5',6'-tetrahydro-1H-spiro[pyridine-4,3'-pyrrolo[3,2-c]pyridin]-2'(1'H)-one (1429043-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 20 °C / Inert atmosphere; Molecular sieve

2.1: triethylamine / dichloromethane / 0.03 h / 0 °C / Inert atmosphere; Molecular sieve

2.2: 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 0 °C / Inert atmosphere

With triethylamine; In dichloromethane;

DOI:10.1021/ol400571j

upstream raw materials:

pyridine-4-carboxylic acid

4-(chlorocarbonyl)pyridine

N-(1-benzylpiperidin-4-ylidene)-1-phenylmethanamine

benzylamine