2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Base Information

Chemical Name:2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester
CAS No.:1025941-03-0
Molecular Formula:C₂₈H₃₆F₃NO₆SSi
Molecular Weight:599.744
Hs Code.:

2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2<i>H</i>-pyridine-1-carboxylic acid methyl ester

Synonyms:2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

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Chemical Property of 2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

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Technology Process of 2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

There total 14 articles about 2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 883142-60-7
(5R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-5-propyl-piperidin-2-one

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 1025941-03-0
2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:: (5R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-5-propyl-piperidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at -78 - -40 ℃;
DOI:10.1055/s-2005-921911

Reference yield:

: (R)-2-(Tetrahydro-pyran-2-yloxymethyl)-pentanal

: 1025941-03-0
2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi

1.2: tetrahydrofuran / 0 - 20 °C

2.1: (DHQD)2PYR; K₂OsO₄; aq. K₂CO₃ / K₃Fe(CN)6 / 2-methyl-propan-2-ol / 0 h

3.1: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

4.1: Et₃N / CH₂Cl₂ / 0 °C

5.1: NaN₃ / dimethylformamide / 80 °C

6.1: PPTS / ethanol / 60 °C

7.1: NaH / tetrahydrofuran / 0 - 20 °C

8.1: 60 percent / H₂ / Pd/C / ethyl acetate / 760 Torr

9.1: LiHMDS / tetrahydrofuran

9.2: 94 percent / tetrahydrofuran / -78 - -40 °C

With dmap; potassium osmate(VI); n-butyllithium; sodium azide; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; potassium hexacyanoferrate(III); In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 2.1: Sharpless asymmetric dihydroxylation / 7.1: Swern oxidation / 8.1: Horner-Emmons reaction;
DOI:10.1055/s-2005-921911

Reference yield:

: 883142-56-1
2-(2-propyl-but-3-enyloxy)-tetrahydro-pyran

: 1025941-03-0
2-(tert-butyl-diphenyl-silanyloxymethyl)-3-propyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: (DHQD)2PYR; K₂OsO₄; aq. K₂CO₃ / K₃Fe(CN)6 / 2-methyl-propan-2-ol / 0 h

2.1: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

3.1: Et₃N / CH₂Cl₂ / 0 °C

4.1: NaN₃ / dimethylformamide / 80 °C

5.1: PPTS / ethanol / 60 °C

6.1: NaH / tetrahydrofuran / 0 - 20 °C

7.1: 60 percent / H₂ / Pd/C / ethyl acetate / 760 Torr

8.1: LiHMDS / tetrahydrofuran

8.2: 94 percent / tetrahydrofuran / -78 - -40 °C

With dmap; potassium osmate(VI); sodium azide; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; potassium hexacyanoferrate(III); In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sharpless asymmetric dihydroxylation / 6.1: Swern oxidation / 7.1: Horner-Emmons reaction;
DOI:10.1055/s-2005-921911