C₄₄H₆₈O₈Si₂

Base Information

Chemical Name:C₄₄H₆₈O₈Si₂
CAS No.:881652-03-5
Molecular Formula:C₄₄H₆₈O₈Si₂
Molecular Weight:781.19
Hs Code.:

C<sub>44</sub>H<sub>68</sub>O<sub>8</sub>Si<sub>2</sub>

Synonyms:C₄₄H₆₈O₈Si₂

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Chemical Property of C₄₄H₆₈O₈Si₂

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Technology Process of C₄₄H₆₈O₈Si₂

There total 27 articles about C₄₄H₆₈O₈Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 782479-10-1
C₃₈H₅₄O₈Si

: 994-30-9
triethylsilyl chloride

: 881652-03-5
C₄₄H₆₈O₈Si₂

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ja054750q

Reference yield:

: 881651-47-4
(E)-(2R,5S)-6-Benzyloxy-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methyl-hex-3-en-2-ol

: 881652-03-5
C₄₄H₆₈O₈Si₂

Guidance literature:: Multi-step reaction with 23 steps

1.1: 97 percent / aq. acetic acid / 5 h / 40 °C

2.1: 70 percent / N-iodosuccinimide; NaHCO₃ / tetrahydrofuran / 36 h / 0 °C

3.1: 99 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 0 - 25 °C

4.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

5.1: 99 percent / H₂ / Raney-Ni / ethanol / 1 h / 25 °C

6.1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 3 h / 25 °C

7.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 25 °C

8.1: Mg / tetrahydrofuran / 2 h / 25 °C

8.2: tetrahydrofuran / 2 h / -78 - 0 °C

9.1: 40.9 g / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 25 °C

10.1: 98 percent / triethyl orthoformate; p-TsOH / 2.5 h / 55 °C

11.1: 96 percent / TBAF / tetrahydrofuran / 48 h / 25 °C

12.1: 97 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 16 h / 0 - 25 °C

13.1: 98 percent / imidazole; 4-DMAP / CH₂Cl₂ / 0.5 h / 0 °C

14.1: N-methylmorpholine-N-oxide; OsO₄ / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 12 h / 25 °C

15.1: 41.5 g / NaIO₄ / 2-methyl-propan-2-ol; H₂O; various solvents / 5 h / 20 °C / pH 7

16.1: n-BuLi / toluene; tetrahydrofuran / 3 h / -30 °C

16.2: tetrahydrofuran; toluene / 1 h / -30 °C

17.1: 13.2 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 0 °C

18.1: 70 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 - -30 °C

19.1: 95 percent / 4-DMAP; pyridine / CH₂Cl₂ / 3 h / 0 - 25 °C

20.1: 91 percent / 2,6-lutidine; N-bromosuccinimide; H₂O / acetonitrile / 2 h / 25 °C

21.1: 92 percent / NaBH₄ / methanol / 0.08 h / -5 °C

22.1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

23.1: 97 percent / imidazole / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; osmium(VIII) oxide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; acetic acid; 4-methylmorpholine N-oxide; triethylamine; orthoformic acid triethyl ester; trifluoroacetic acid; palladium dihydroxide; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; various solvents; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja054750q

Reference yield:

: 881651-49-6
(2S,3R,5S)-2-((1S,2R)-3-Benzyloxy-1-iodo-2-methyl-propyl)-5-hydroxymethyl-tetrahydro-furan-3-ol

: 881652-03-5
C₄₄H₆₈O₈Si₂

Guidance literature:: Multi-step reaction with 21 steps

1.1: 99 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 0 - 25 °C

2.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 99 percent / H₂ / Raney-Ni / ethanol / 1 h / 25 °C

4.1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 3 h / 25 °C

5.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 25 °C

6.1: Mg / tetrahydrofuran / 2 h / 25 °C

6.2: tetrahydrofuran / 2 h / -78 - 0 °C

7.1: 40.9 g / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 25 °C

8.1: 98 percent / triethyl orthoformate; p-TsOH / 2.5 h / 55 °C

9.1: 96 percent / TBAF / tetrahydrofuran / 48 h / 25 °C

10.1: 97 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 16 h / 0 - 25 °C

11.1: 98 percent / imidazole; 4-DMAP / CH₂Cl₂ / 0.5 h / 0 °C

12.1: N-methylmorpholine-N-oxide; OsO₄ / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 12 h / 25 °C

13.1: 41.5 g / NaIO₄ / 2-methyl-propan-2-ol; H₂O; various solvents / 5 h / 20 °C / pH 7

14.1: n-BuLi / toluene; tetrahydrofuran / 3 h / -30 °C

14.2: tetrahydrofuran; toluene / 1 h / -30 °C

15.1: 13.2 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 0 °C

16.1: 70 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 - -30 °C

17.1: 95 percent / 4-DMAP; pyridine / CH₂Cl₂ / 3 h / 0 - 25 °C

18.1: 91 percent / 2,6-lutidine; N-bromosuccinimide; H₂O / acetonitrile / 2 h / 25 °C

19.1: 92 percent / NaBH₄ / methanol / 0.08 h / -5 °C

20.1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

21.1: 97 percent / imidazole / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; water; hydrogen; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; 4-methylmorpholine N-oxide; triethylamine; orthoformic acid triethyl ester; trifluoroacetic acid; palladium dihydroxide; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; various solvents; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja054750q