Galidesivir

Base Information

Chemical Name:Galidesivir
CAS No.:249503-25-1
Molecular Formula:C₁₁H₁₅N₅O₃
Molecular Weight:265.272
Hs Code.:
UNII:OLF97F86A7
Nikkaji Number:J1.272.375J,J1.666.735H
Wikipedia:Galidesivir
Wikidata:Q76415680
NCI Thesaurus Code:C172613
Pharos Ligand ID:QMURXRGFQ4XM
Metabolomics Workbench ID:144549
ChEMBL ID:CHEMBL1236524

Synonyms:2-(4-amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;BCX-4430;BCX4430;Galidesivir;ImmA cpd;immucillin A;immucillin-A

Suppliers and Price of Galidesivir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
BCX4430freebase >98%
5 mg
$ 1600.00

Crysdot
BCX4430freebase 98+%
1mg
$ 1080.00

ChemScene
Galidesivir 99.29%
5mg
$ 2400.00

ChemScene
Galidesivir 99.29%
1mg
$ 600.00

Cayman Chemical
BCX4430 ≥98%
1mg
$ 600.00

Cayman Chemical
BCX4430 ≥98%
500μg
$ 375.00

Biorbyt Ltd
BCX4430 freebase
5 mg
$ 2395.30

AK Scientific
Galidesivir
1mg
$ 910.00

Total 14 raw suppliers

Chemical Property of Galidesivir

Chemical Property:

Boiling Point:661.2±55.0 °C(Predicted)
PKA:13.78±0.40(Predicted)
PSA：140.31000
Density:1.630±0.06 g/cm3(Predicted)
LogP:-0.82290
XLogP3:-2.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:265.11748936
Heavy Atom Count:19
Complexity:334

Purity/Quality:

97% ^*data from raw suppliers

BCX4430freebase >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C2=C(N1)C(=NC=N2)N)C3C(C(C(N3)CO)O)O
Isomeric SMILES:C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
Recent ClinicalTrials:A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430

Technology Process of Galidesivir

There total 20 articles about Galidesivir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (2S,3S,4S,5R)-tert-butyl 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1610426-08-8,249503-25-1
(2S,3S,4S,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Guidance literature:: With hydrogenchloride; water; In ethanol; at 20 ℃; for 0.5h;

Reference yield: 15.3%

: 1610426-02-2
(2S,3R,4R,5R)-tert-butyl 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1610426-01-1,249503-25-1
(2S,3R,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.5h;

Reference yield:

: 153172-31-7
(3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole

: 249503-25-1
(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 10 steps

1.1: NCS / pentane / 1 h

1.2: LiTMP / tetrahydrofuran / -78 °C

2.1: 0.83 g / tetrahydrofuran / 1 h / -78 °C

3.1: 85 percent / CH₂Cl₂ / 16 h / 20 °C

4.1: dimethylformamide / 1 h / 65 - 70 °C

5.1: 0.68 g / aq. AcOH / tetrahydrofuran / 1.5 h / 20 °C

6.1: NaOAc / methanol / 16 h / 20 °C

7.1: DBU / CH₂Cl₂ / 4 h / Heating

8.1: H₂ / Pd/C / ethanol / 3 h

9.1: ethanol / 16 h / Heating

10.1: aq. TFA

With N-chloro-succinimide; hydrogen; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane; 1.1: Chlorination / 1.2: Elimination / 2.1: Addition / 3.1: Substitution / 4.1: Condensation / 5.1: Hydrolysis / 6.1: Condensation / 7.1: Substitution / 8.1: Hydrogenolysis / 9.1: Cyclization / 10.1: Hydrolysis;
DOI:10.1016/S0040-4020(00)00194-0