2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

Base Information

• Chemical Name: 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide
• CAS No.: 302554-32-1
• Molecular Formula: C₁₈H₁₇N₃O₂S
• Molecular Weight: 339.418

Synonyms:2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

Chemical Property of 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

Chemical Property:

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Technology Process of 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

There total 5 articles about 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(4-methoxyphenyl)-2-sulfanylidene-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile (120517-49-9) + Chloroacetamide (79-07-2) → 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide (302554-32-1)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

Reference yield:

2-cyano-3-(4-methoxyphenyl)thioacrylamide (68029-57-2) → 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide (302554-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 3 h / Heating

1.2: Et₃N / ethanol / 2 h / Heating

2.1: NaOEt / ethanol / 1 h / Heating

3.1: 81 percent / CH₃CO₂Na*3H₂O / ethanol / 2 h / Heating

With piperidine; sodium ethanolate; sodium acetate; In ethanol;

Reference yield:

cyclopentanone (120-92-3) → 2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide (302554-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 3 h / Heating

1.2: Et₃N / ethanol / 2 h / Heating

2.1: NaOEt / ethanol / 1 h / Heating

3.1: 81 percent / CH₃CO₂Na*3H₂O / ethanol / 2 h / Heating

With piperidine; sodium ethanolate; sodium acetate; In ethanol;

upstream raw materials:

4-(4-methoxyphenyl)-2-sulfanylidene-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile

Chloroacetamide

2-(4-methoxybenzylidene)cyclopentanone

2-cyano-3-(4-methoxyphenyl)thioacrylamide

Downstream raw materials:

10-(p-methoxyphenyl)-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxocyclopenta-[5',6']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

4-(3,5-dimethyl-1H-pyrazol-1-yl)-10-(p-methoxyphenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

4-hydrazino-10-(p-methoxyphenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

10-(p-methoxyphenyl)cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

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