1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

Base Information

Chemical Name:1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea
CAS No.:1442474-06-7
Molecular Formula:C₃₀H₃₂F₃N₇O₂
Molecular Weight:579.625
Hs Code.:

Synonyms:1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

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Chemical Property of 1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

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Technology Process of 1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

There total 17 articles about 1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1442474-04-5
prop-1-en-2-yl (5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)carbamate

: 1310680-05-7
4-fluoro-3-((4-methylpiperazin-1-yl)methyl)aniline

: 1442474-06-7
1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

Guidance literature:: With 1-Methylpyrrolidine; In 1,4-dioxane; at 80 ℃;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442474-06-7
1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 90 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 5 h / 160 °C

5: trifluoroacetic acid / 1.5 h / 20 °C

6: sodium hydrogencarbonate / ethyl acetate / 20 °C

7: 1-Methylpyrrolidine / 1,4-dioxane / 80 °C

With 1-Methylpyrrolidine; manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 959162-99-3
(6-chloro-4-(ethylamino)pyridin-3-yl)methanol

: 1442474-06-7
1-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2,4-difluorophenyl)-3-(4-fluoro-3-((4-methylpiperazin-1-yl)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 90 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 5 h / 160 °C

4: trifluoroacetic acid / 1.5 h / 20 °C

5: sodium hydrogencarbonate / ethyl acetate / 20 °C

6: 1-Methylpyrrolidine / 1,4-dioxane / 80 °C

With 1-Methylpyrrolidine; manganese(IV) oxide; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;