methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate

Base Information

• Chemical Name: methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate
• CAS No.: 123883-75-0
• Molecular Formula: C₁₄H₁₆O₃Se
• Molecular Weight: 311.239
• Mol file: 123883-75-0.mol

Synonyms:methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate

Chemical Property of methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate

There total 3 articles about methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 2-acetylpent-4-enoate (3897-04-9) + diphenyl diselenide (1666-13-3) → methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate (123883-75-0)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; acetic acid; In acetonitrile; at 0 ℃; Inert atmosphere; Electrochemical reaction; Green chemistry;

DOI:10.1039/c9gc02665g

Reference yield:

acetoacetic acid methyl ester (105-45-3) → methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate (123883-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: tetrabutylammonium tetrafluoroborate; acetic acid / acetonitrile / 0 °C / Inert atmosphere; Electrochemical reaction; Green chemistry

With tetrabutylammonium tetrafluoroborate; sodium hydride; acetic acid; In tetrahydrofuran; acetonitrile;

DOI:10.1039/c9gc02665g

Reference yield:

methyl 2-acetylpent-4-enoate (3897-04-9) + Phenylselenyl bromide (34837-55-3) → methyl 2-methyl-5-((phenylselanyl)methyl)-4,5-dihydrofuran-3-carboxylate (123883-75-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.3184/030823408X320629

upstream raw materials:

methyl 2-acetylpent-4-enoate

diphenyl diselenide

Phenylselenyl bromide

acetoacetic acid methyl ester

Downstream raw materials:

Methyl-2-methyl-5-methoxy-methyl-3-furoat

5-ethoxymethyl-2-methylfuran-3-carboxylic acid methyl ester

methyl 2,5-dimethylfuran-3-carboxylate