2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

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Chemical Name:2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid
CAS No.:1428794-21-1
Molecular Formula:C₃₂H₃₅FN₂O₅
Molecular Weight:546.639
Hs Code.:

Synonyms:2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

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Chemical Property of 2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

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Technology Process of 2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

There total 13 articles about 2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.7%

: 1428794-84-6
methyl 2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate

: 1428794-21-1
2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate; With methanol; lithium hydroxide; In tetrahydrofuran; at 60 ℃;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: methyl 2-(1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-hydroxyacetate

: 1428794-21-1
2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: perchloric acid / 0 - 20 °C

2.1: water; sodium hydroxide / methanol; tetrahydrofuran / 3 h / 70 °C

2.2: 0 °C / pH < 2

3.1: potassium hexamethylsilazane / tetrahydrofuran / 50 - 70 °C

3.2: 0 °C

4.1: methanol / 0.17 h / 20 °C

5.1: caesium carbonate / acetonitrile / 1.5 h / 70 °C

6.1: lithium hydroxide; methanol / tetrahydrofuran / 60 °C

With methanol; perchloric acid; water; potassium hexamethylsilazane; caesium carbonate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1428794-74-4
1-benzyl-5-(hydroxymethyl)-6-methyl-4-(5-methylchroman-6-yl)-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

: 1428794-21-1
2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.67 h / -78 °C

1.2: 6 h / -78 °C

2.1: zinc(II) iodide / dichloromethane / 0.17 h / 20 °C

3.1: hydrogenchloride; water / dichloromethane / 2 h / 20 °C

4.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

5.1: sodium hydroxide / ethanol / 140 °C / Sealed tube

5.2: pH < 2

6.1: perchloric acid / 0 - 20 °C

7.1: water; sodium hydroxide / methanol; tetrahydrofuran / 3 h / 70 °C

7.2: 0 °C / pH < 2

8.1: potassium hexamethylsilazane / tetrahydrofuran / 50 - 70 °C

8.2: 0 °C

9.1: methanol / 0.17 h / 20 °C

10.1: caesium carbonate / acetonitrile / 1.5 h / 70 °C

11.1: lithium hydroxide; methanol / tetrahydrofuran / 60 °C

With hydrogenchloride; methanol; perchloric acid; oxalyl dichloride; water; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; caesium carbonate; dimethyl sulfoxide; sodium hydroxide; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;