1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

Base Information

Chemical Name:1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde
CAS No.:1428794-75-5
Molecular Formula:C₂₆H₂₄N₂O₃
Molecular Weight:412.488
Hs Code.:

Synonyms:1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

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Chemical Property of 1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

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Technology Process of 1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

There total 1 articles about 1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.8%

: 1428794-74-4
1-benzyl-5-(hydroxymethyl)-6-methyl-4-(5-methylchroman-6-yl)-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

: 1428794-75-5
1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

Guidance literature:: 1-benzyl-5-(hydroxymethyl)-6-methyl-4-(5-methylchroman-6-yl)-1H-pyrrolo[2,3-c]pyridin-7(6H)-one; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.666667h;

With triethylamine; In dichloromethane; at -78 ℃; for 6h;

Reference yield: 95.0%

: 7677-24-9
trimethylsilyl cyanide

: 1428794-75-5
1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

: 1428794-77-7
2-(1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:: With zinc(II) iodide; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 1428794-75-5
1-benzyl-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-carbaldehyde

: 1428794-21-1
2-(tert-butoxy)-2-(1-(3-fluoro-4-methylbenzyl)-6-methyl-4-(5-methylchroman-6-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: zinc(II) iodide / dichloromethane / 0.17 h / 20 °C

2.1: hydrogenchloride; water / dichloromethane / 2 h / 20 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

4.1: sodium hydroxide / ethanol / 140 °C / Sealed tube

4.2: pH < 2

5.1: perchloric acid / 0 - 20 °C

6.1: water; sodium hydroxide / methanol; tetrahydrofuran / 3 h / 70 °C

6.2: 0 °C / pH < 2

7.1: potassium hexamethylsilazane / tetrahydrofuran / 50 - 70 °C

7.2: 0 °C

8.1: methanol / 0.17 h / 20 °C

9.1: caesium carbonate / acetonitrile / 1.5 h / 70 °C

10.1: lithium hydroxide; methanol / tetrahydrofuran / 60 °C

With hydrogenchloride; methanol; perchloric acid; water; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; caesium carbonate; sodium hydroxide; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;