(3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene

Base Information

• Chemical Name: (3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene
• CAS No.: 93474-71-6
• Molecular Formula: C₁₄H₂₁NO₄S
• Molecular Weight: 299.391
• Mol file: 93474-71-6.mol

Synonyms:(3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene

Chemical Property of (3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene

There total 1 articles about (3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(3S,4S,5S)-N-(phenylsulfonyl)-4-amino-3,5-dihydroxy-3-methyl-1-hexene (93474-60-3) + methyl iodide (74-88-4) → (3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene (93474-71-6)

Guidance literature:

With potassium carbonate; In isopropyl alcohol; at 65 ℃; for 36h;

DOI:10.1021/jo00203a008

Reference yield:

(3S,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-amino-3,5-dihydroxy-1-hexene (93474-71-6) → (2R,3R,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-aminohexane-1,2,3,5-tetrol (93601-16-2) + (2S,3R,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-aminohexane-1,2,3,5-tetrol (93474-72-7)

Guidance literature:

With osmium(VIII) oxide; sodium dithionite; 4-methylmorpholine N-oxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) acetone, t-BuOH, RT, 48 h, 2.) acetone, t-BuOH, 30 min;

DOI:10.1021/jo00203a008

upstream raw materials:

(3S,4S,5S)-N-(phenylsulfonyl)-4-amino-3,5-dihydroxy-3-methyl-1-hexene

methyl iodide

Downstream raw materials:

(2R,3R,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-aminohexane-1,2,3,5-tetrol

(2S,3R,4S,5S)-N-(phenylsulfonyl)-N,3-dimethyl-4-aminohexane-1,2,3,5-tetrol