(S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

Base Information

Chemical Name:(S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide
CAS No.:1397283-02-1
Molecular Formula:C₃₇H₃₈N₂O₂P₂
Molecular Weight:604.668
Hs Code.:

Synonyms:(S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

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Chemical Property of (S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

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Technology Process of (S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

There total 7 articles about (S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1397283-08-7
C₂₅H₂₉N₂OP

: 1499-21-4
Diphenylphosphinic chloride

: 1397283-02-1
(S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.07.062

Reference yield: 5.0%

: C₁₃H₂₀N₂

: 1499-21-4
Diphenylphosphinic chloride

: 1397283-02-1
(S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.07.062

Reference yield:

: 608533-84-2
(S)-1-(Diphenyl-phosphinoyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1397283-02-1
(S)-N-((1-(diphenylphosphoryl)pyrrolidin-2-yl)methyl)-N-phenethyl-P,P-diphenylphosphinic amide

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -50 - 20 °C / Inert atmosphere

3: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With oxalyl dichloride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1016/j.tet.2012.07.062