(1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

Base Information

Chemical Name:(1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide
CAS No.:1383746-33-5
Molecular Formula:C₂₃H₂₄N₄O₄
Molecular Weight:420.468
Hs Code.:

Synonyms:(1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

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Chemical Property of (1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

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Technology Process of (1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

There total 8 articles about (1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383747-30-5
(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarboxylic acid

: 64436-92-6
3-amino-5-methoxypyridine

: 1383746-33-5
(1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 10 - 35 ℃; for 20h;

Reference yield:

: 140-29-4
phenylacetonitrile

: 1383746-33-5
(1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / Cooling with ice-salt

1.2: 0 - 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 35 °C

2.2: Cooling with ice

3.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / -15 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 35 °C

7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

7.2: 1 h / 10 - 35 °C

8.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 2 h / 10 - 35 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 20 h / 10 - 35 °C

With 1H-imidazole; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 7.1: Swern Oxidation;

Reference yield:

: 63106-93-4,96847-52-8,96847-75-5,96847-53-9
(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 1383746-33-5
(1R,2S)-2-[(1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl]-N-(5-methoxypyridin-3-yl)-2-phenylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 35 °C

1.2: Cooling with ice

2.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / -15 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 35 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

6.2: 1 h / 10 - 35 °C

7.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 2 h / 10 - 35 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 20 h / 10 - 35 °C

With 1H-imidazole; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 6.1: Swern Oxidation;