N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

Base Information

Chemical Name:N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide
CAS No.:127019-50-5
Molecular Formula:C₂₈H₃₀N₃O₄S*I
Molecular Weight:631.534
Hs Code.:

Synonyms:N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

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Chemical Property of N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

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Technology Process of N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

There total 6 articles about N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 127019-49-2
N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamidethieno<2,3-b>pyridine

: 74-88-4
methyl iodide

: 127019-50-5
N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

Guidance literature:: In acetonitrile; for 24h; Heating;
DOI:10.1002/jhet.5570260616

Reference yield:

: 40357-96-8
5-nitro-thiophene-3-carboxylic acid

: 127019-50-5
N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Sn, HCl, 2.) HCl / 1.) 40 - 45 deg C, 2.) methanol, reflux, 24 h, room temperature, 24 h

2: 74 percent / 20percent NaOH / ethanol / 36 h / Heating

3: SOCl₂ / 12 h / Heating

4: triethyl amine / CH₂Cl₂ / 12 h / Ambient temperature

5: 73 percent / acetonitrile / 24 h / Heating

With hydrogenchloride; sodium hydroxide; tin; thionyl chloride; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1002/jhet.5570260616

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 127019-50-5
N,N'-3,5-((S)-1-hydroxymethyl-2-phenylethyl)dicarboxamide-7-methylthieno<2,3-b>pyridinium iodide

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / HNO₃, H₂SO₄ / -10 - -5 °C

2: 1.) Sn, HCl, 2.) HCl / 1.) 40 - 45 deg C, 2.) methanol, reflux, 24 h, room temperature, 24 h

3: 74 percent / 20percent NaOH / ethanol / 36 h / Heating

4: SOCl₂ / 12 h / Heating

5: triethyl amine / CH₂Cl₂ / 12 h / Ambient temperature

6: 73 percent / acetonitrile / 24 h / Heating

With hydrogenchloride; sodium hydroxide; tin; thionyl chloride; sulfuric acid; nitric acid; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1002/jhet.5570260616