6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Base Information

• Chemical Name: 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
• CAS No.: 250210-28-7
• Molecular Formula: C₄₀H₆₀O₄
• Molecular Weight: 604.914
• Mol file: 250210-28-7.mol

Synonyms:6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property of 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

There total 5 articles about 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + cholesteryl ω-bromohexanoate (82962-33-2) → 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (250210-28-7)

Guidance literature:

With potassium carbonate; In butanone; for 12h; Reflux;

DOI:10.1002/cphc.201900716

Reference yield:

6-bromohexanoyl chloride (22809-37-6) → 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (250210-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / K₂CO₃ / dimethylformamide / 16 h / 85 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2005.07.132

Reference yield:

cholesterol (57-88-5) → 6-(4-Formyl-phenoxy)-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (250210-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / K₂CO₃ / dimethylformamide / 16 h / 85 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2005.07.132

upstream raw materials:

4-hydroxy-benzaldehyde

cholesteryl ω-bromohexanoate

6-bromohexanoyl chloride

cholesterol

Downstream raw materials:

C₄₆H₆₆N₂O₆