benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Base Information

Chemical Name:benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate
CAS No.:865487-55-4
Molecular Formula:C₂₃H₂₆N₂O₆
Molecular Weight:426.469
Hs Code.:

Synonyms:benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Suppliers and Price of benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

There total 7 articles about benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865487-27-0
benzyl (2R,3R,4'S)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(4'-thiophenyl-2-'oxoazetidin-1'-yl)pentanoate

: 865487-55-4
benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In benzene; for 19h; Heating;
DOI:10.1021/ja992649d

Reference yield:

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 865487-55-4
benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / tetrahydrofuran / 2 h / 0 °C

2.1: aq. sodium borohydride / tetrahydrofuran / 5 h / 0 °C

3.1: (COCl)2; DMSO / CH₂Cl₂ / 0.25 h / -78 °C

4.1: LHMDS / tetrahydrofuran; hexane / 2 h / -78 °C

4.2: hexane; tetrahydrofuran / 2 h

5.1: tris(trimethylsilyl)silyl hydride; AIBN / benzene / 19 h / Heating

With sodium tetrahydroborate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; benzene; 1.1: Condensation / 2.1: Reduction / 3.1: Swern oxidation / 4.1: Metallation / 4.2: Addition / 5.1: Reduction;
DOI:10.1021/ja992649d

Reference yield:

: 65564-05-8
3-[(benzyloxycarbonyl)amino]propanal

: 865487-55-4
benzyl (2R,3R)-5-(N-benzyloxycarbonyl)-amino-3-hydroxy-2-(2-'oxoazetidin-1'-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: LHMDS / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: hexane; tetrahydrofuran / 2 h

2.1: tris(trimethylsilyl)silyl hydride; AIBN / benzene / 19 h / Heating

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; benzene; 1.1: Metallation / 1.2: Addition / 2.1: Reduction;
DOI:10.1021/ja992649d