2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

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Chemical Name:2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite
CAS No.:1360744-36-0
Molecular Formula:C₅₃H₇₂N₇O₁₃P
Molecular Weight:1046.17
Hs Code.:

Synonyms:2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

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Chemical Property of 2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

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Technology Process of 2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

There total 6 articles about 2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360744-35-9
2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1360744-36-0
2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

Guidance literature:: With 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 2.66667h;
DOI:10.1016/j.bmc.2011.12.024

Reference yield:

: 864837-09-2
N³-benzoyl-2'-O-(2-cyanoethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1360744-36-0
2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia; hydrogen / methanol / 1 h / 20 °C / 22502.3 Torr / Autoclave

2: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

3: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 1 h / 20 °C

4: pyridine / 5 h / 20 °C

5: 4,5-dicyano-1H-imidazole / dichloromethane / 2.67 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; ammonia; hydrogen; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.12.024

Reference yield:

: 1360744-34-8
2'-O-(N,N'-di-Boc-guanidinopropyl)-uridine

: 1360744-36-0
2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 5 h / 20 °C

2: 4,5-dicyano-1H-imidazole / dichloromethane / 2.67 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; In dichloromethane;
DOI:10.1016/j.bmc.2011.12.024