2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

Base Information

Chemical Name:2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide
CAS No.:1345183-05-2
Molecular Formula:C₂₁H₂₂FN₃O₄S
Molecular Weight:431.488
Hs Code.:

Synonyms:2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

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Chemical Property of 2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

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Technology Process of 2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

There total 7 articles about 2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345183-08-5
2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methylene-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

: 1345183-05-2
2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

Guidance literature:: With hydrogen; 20% palladium hydroxide-activated charcoal; In methanol; ethyl acetate; at 20 ℃; for 1.5h;

Reference yield:

: 5154-00-7,59315-47-8
6-amino-pyridin-2-ol

: 1345183-05-2
2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-iodo-succinimide; acetic acid / 1 h

2.1: 1 h / 110 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 - 20 °C / Inert atmosphere

3.2: 7 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 16 h / 0 - 5 °C

4.2: 0 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation

6.1: triethylamine / palladium diacetate / N,N-dimethyl-formamide / 0.75 h / 120 °C / Microwave irradiation

7.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol; ethyl acetate / 1.5 h / 20 °C

With N-iodo-succinimide; hydrogen; caesium carbonate; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 20% palladium hydroxide-activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1345173-96-7
acetic acid 6-diacetylamino-3,5-diiodo-pyridin-2-yl ester

: 1345183-05-2
2-(4-fluoro-phenyl)-9-methanesulfonyl-5-methyl-6,7,8,9-tetrahydro-5H-1-oxa-9,10-diaza-cyclohepta[f]indene-3-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 - 20 °C / Inert atmosphere

1.2: 7 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 16 h / 0 - 5 °C

2.2: 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation

4.1: triethylamine / palladium diacetate / N,N-dimethyl-formamide / 0.75 h / 120 °C / Microwave irradiation

5.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol; ethyl acetate / 1.5 h / 20 °C

With hydrogen; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 20% palladium hydroxide-activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;