({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene

Base Information

• Chemical Name: ({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene
• CAS No.: 1220328-94-8
• Molecular Formula: C₁₈H₂₈O₄
• Molecular Weight: 308.418
• Mol file: 1220328-94-8.mol

Synonyms:({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene

Chemical Property of ({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene

There total 2 articles about ({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-1-benzyloxypent-4-en-2-ol (58931-16-1,88981-35-5,110339-28-1) + Bromoacetaldehyde diethyl acetal (2032-35-1) → ({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene (1220328-94-8)

Guidance literature:

(R)-1-benzyloxypent-4-en-2-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.75h;

Bromoacetaldehyde diethyl acetal; In tetrahydrofuran; mineral oil; at 70 ℃; for 24h;

Reference yield:

(R)-benzyl glycidol (14618-80-5) → ({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene (1220328-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide / diethyl ether; tetrahydrofuran / 18 h / -78 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 42 h / 0 °C / Reflux

With copper(l) iodide; sodium hydride; In tetrahydrofuran; diethyl ether; mineral oil;

Reference yield: 87.0%

({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene (1220328-94-8) → {[(2R)-1-(benzyloxy)pent-4-en-2-yl]oxy}acetaldehyde (1425947-51-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 75 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm501833t

upstream raw materials:

(R)-1-benzyloxypent-4-en-2-ol

Bromoacetaldehyde diethyl acetal

(R)-benzyl glycidol

Downstream raw materials:

{[(2R)-1-(benzyloxy)pent-4-en-2-yl]oxy}acetaldehyde

2-{[(2R)-1-(benzyloxy)pent-4-en-2-yl]oxy}-N-hydroxyethanimine

(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

(3aR,5R)-5-[(benzyloxy)methyl]-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole