N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine

Base Information

• Chemical Name: N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine
• CAS No.: 1476068-48-0
• Molecular Formula: C₂₇H₃₂BrN₃O₅
• Molecular Weight: 558.472
• Mol file: 1476068-48-0.mol

Synonyms:N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine

Chemical Property of N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine

There total 5 articles about N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucinate (1476068-51-5) → N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine (1476068-48-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-0033-1338497

Reference yield:

1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (1279881-34-3) → N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine (1476068-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; isobutyl chloroformate / acetonitrile / 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With triethylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; acetonitrile;

DOI:10.1055/s-0033-1338497

Reference yield:

2-isopropylaniline (643-28-7) → N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine (1476068-48-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 0.5 h / 0 °C

2.3: 0.33 h / Reflux

3.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

4.1: triethylamine; isobutyl chloroformate / acetonitrile / 20 °C / Inert atmosphere

4.2: 5 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; ammonium acetate; water; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium nitrite; isobutyl chloroformate; In 1,4-dioxane; dichloromethane; water; acetonitrile;

DOI:10.1055/s-0033-1338497

upstream raw materials:

1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

tert-butyl N-{[1-(4-bromo-2-isopropylphenyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucinate

2-isopropylaniline

4-bromo-2-isopropyl-aniline

Downstream raw materials:

N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-leucine