C₄₁H₅₇F₃N₁₀O₇S₂

Base Information

• Chemical Name: C₄₁H₅₇F₃N₁₀O₇S₂
• CAS No.: 943601-18-1
• Molecular Formula: C₄₁H₅₇F₃N₁₀O₇S₂
• Molecular Weight: 923.094
• Mol file: 943601-18-1.mol

Synonyms:C₄₁H₅₇F₃N₁₀O₇S₂

Chemical Property of C₄₁H₅₇F₃N₁₀O₇S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₅₇F₃N₁₀O₇S₂

There total 10 articles about C₄₁H₅₇F₃N₁₀O₇S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H43F3N8O5S + biotin pentafluorophenyl ester (120550-35-8) → C41H57F3N10O7S2 (943601-18-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/ol070376i

Reference yield:

tert-butyl 8-{[(2-nitrophenyl)sulfonyl]amino}octylcarbamate (606969-00-0) → C41H57F3N10O7S2 (943601-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0.33 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 0 °C

3: 1.2 g / triethylamine / dimethylformamide / 2 h / 20 °C

With triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Mitsunobu reaction;

DOI:10.1021/ol070376i

Reference yield:

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde (943601-13-6) → C41H57F3N10O7S2 (943601-18-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 822 mg / sodium borohydride / ethanol / 0.17 h / 0 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

3: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

4: 100 percent / (+)-camphorsulfonic acid / methanol / 0.5 h / 20 °C

5: 92 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0.33 h / 20 °C

6: trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 0 °C

7: 1.2 g / triethylamine / dimethylformamide / 2 h / 20 °C

With sodium tetrahydroborate; sodium azide; tetra-(n-butyl)ammonium iodide; (+)-10-camphorsulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5: Mitsunobu reaction;

DOI:10.1021/ol070376i

upstream raw materials:

biotin pentafluorophenyl ester

tert-butyl 8-{[(2-nitrophenyl)sulfonyl]amino}octylcarbamate

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

C₂₂H₃₁F₃N₂O₄

Downstream raw materials:

C₃₅H₅₄F₃N₉O₃S