2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

Base Information

• Chemical Name: 2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde
• CAS No.: 943601-13-6
• Molecular Formula: C₂₂H₂₉F₃N₂O₄
• Molecular Weight: 442.478
• Mol file: 943601-13-6.mol

Synonyms:2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

Chemical Property of 2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

There total 1 articles about 2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(8-bromooctyloxy)tetrahydropyran (50816-20-1) + 2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (308085-25-8) → 2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde (943601-13-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

DOI:10.1021/ol070376i

Reference yield:

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde (943601-13-6) → C22H31F3N2O4 (943601-14-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.166667h;

DOI:10.1021/ol070376i

Reference yield:

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde (943601-13-6) → 2-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzyl methanesulfonate (943601-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 822 mg / sodium borohydride / ethanol / 0.17 h / 0 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane;

DOI:10.1021/ol070376i

upstream raw materials:

2-(8-bromooctyloxy)tetrahydropyran

2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde

Downstream raw materials:

C₂₂H₃₁F₃N₂O₄

C₄₁H₅₇F₃N₁₀O₇S₂

C₃₅H₅₄F₃N₉O₃S

2-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzyl methanesulfonate