10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine

Base Information

• Chemical Name: 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine
• CAS No.: 473264-15-2
• Molecular Formula: C₂₇H₂₀ClF₃N₂O₂
• Molecular Weight: 496.916

Synonyms:10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine

Chemical Property of 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine

Chemical Property:

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Technology Process of 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine

There total 1 articles about 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-2'-trifluoromethyl-5-methoxy-[1,1'-biphenyl]-4-carboxylic acid (473264-14-1) + 10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine (22162-53-4) → 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine (473264-15-2)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; triethylamine;

Reference yield:

10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine (473264-15-2) + 3-methyl-N-(3-methylbutyl)-1-butanamine (544-00-3) + trifluoroacetyl chloride (76-02-8) → 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid (473260-70-7)

Guidance literature:

With sodium hydroxide; In dichloromethane; acetone;

Reference yield:

10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepine (473264-15-2) + trifluoroacetyl chloride (76-02-8) → 10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid (473260-70-7)

Guidance literature:

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

upstream raw materials:

2-chloro-2'-trifluoromethyl-5-methoxy-[1,1'-biphenyl]-4-carboxylic acid

10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

Downstream raw materials:

10-{[6-chloro-3-methoxy-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid

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