3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one

Base Information

• Chemical Name: 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one
• CAS No.: 91021-92-0
• Molecular Formula: C₁₃H₁₇N₅O₅
• Molecular Weight: 323.308

Synonyms:3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one

Chemical Property of 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one

There total 1 articles about 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Deoxyguanosine (961-07-9) + acrolein (107-02-8,25068-14-8) → 3H-8-hydroxy-3-(β-D-2′-deoxyribofuranosyl)-5,6,7,8-tetrahydropyrido[3,2-a]purine-9-one (91021-93-1) + 7,8-dihydro-8-oxo-2'-deoxyguanosine (88847-89-6) + 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one (91021-92-0)

Guidance literature:

In aq. phosphate buffer; at 37 ℃; for 48h; pH=7;

DOI:10.1021/ac3034695

Reference yield:

3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one (91021-92-0) → 1,N2-propano-2'-deoxyguanosine

Guidance literature:

With sodium cyanoborohydride; In phosphate buffer; at 20 - 40 ℃; for 192h; pH=7.0;

DOI:10.1021/tx010181y

Reference yield:

3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one (91021-92-0) → 1,N2-propano-2'-deoxyguanosine + 1-(3-hydroxypropyl)-2'-deoxyguanosine

Guidance literature:

With sodium tetrahydroborate; In phosphate buffer; at 20 ℃; for 120h; pH=7.0;

DOI:10.1021/tx010181y

upstream raw materials:

2'-Deoxyguanosine

acrolein

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