Technology Process of 4-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)naphthalen-2-yl)-N-methylbenzenamine
There total 12 articles about 4-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)naphthalen-2-yl)-N-methylbenzenamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
formaldehyd; 4-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)naphthalen-2-yl)benzenamine;
With
sodium methylate;
In
methanol;
for 1.5h;
Heating / reflux;
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
for 1.5h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / 2 h / 100 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 180 °C / microwave irradiation
4.1: hydrogenchloride; tin(ll) chloride / ethanol / 2 h / Heating / reflux
5.1: sodium methylate / methanol / 1.5 h / Heating / reflux
5.2: 1.5 h / 0 °C / Heating / reflux
With
hydrogenchloride; tetrabutyl ammonium fluoride; water; sodium methylate; sodium carbonate; potassium carbonate; tin(ll) chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 1H-imidazole / dichloromethane / 2 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.83 h / -78 °C
3.1: tetrahydrofuran / 0.33 h / -78 - 20 °C
4.1: hydrogenchloride; water / tetrahydrofuran / Acidic conditions
5.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / 2 h / 100 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 180 °C / microwave irradiation
8.1: hydrogenchloride; tin(ll) chloride / ethanol / 2 h / Heating / reflux
9.1: sodium methylate / methanol / 1.5 h / Heating / reflux
9.2: 1.5 h / 0 °C / Heating / reflux
With
1H-imidazole; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium methylate; sodium carbonate; potassium carbonate; tin(ll) chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
