3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Chemical Name:3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one
CAS No.:1239911-35-3
Molecular Formula:C₃₀H₃₀N₆O₄
Molecular Weight:538.606
Hs Code.:

Synonyms:3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Chemical Property of 3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Technology Process of 3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

There total 4 articles about 3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

: 1239911-41-1
4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

: 530-62-1
1,1'-carbonyldiimidazole

: 1239911-35-3
3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 148564-09-4
methyl 2'-cyano-α-(1-oxopentyl)<1,1'-biphenyl>-4-propanoate

: 1239911-35-3
3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate; acetic acid / toluene / 4 h / Reflux

2.1: acetic acid / 3 h / 20 - 70 °C

3.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1.25 h / 20 °C

3.2: 12 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

5.1: potassium carbonate / acetonitrile / 65 °C

6.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 90 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 20 °C

With hydroxylamine hydrochloride; ammonium acetate; hydrogen; trimethylaluminum; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In methanol; n-heptane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: C₂₂H₂₄N₂O₂

: 1239911-35-3
3-{4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 3 h / 20 - 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1.25 h / 20 °C

2.2: 12 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

4.1: potassium carbonate / acetonitrile / 65 °C

5.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 90 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 20 °C

With hydroxylamine hydrochloride; hydrogen; trimethylaluminum; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In methanol; n-heptane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;