4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

Base Information

Chemical Name:4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide
CAS No.:1239911-41-1
Molecular Formula:C₂₉H₃₂N₆O₃
Molecular Weight:512.611
Hs Code.:

Synonyms:4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

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Chemical Property of 4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

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Technology Process of 4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

There total 4 articles about 4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239911-40-0
4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

: 1239911-41-1
4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In dimethyl sulfoxide; at 90 ℃;

Reference yield:

: 1239911-37-5
methyl (Z)-3-acetamido-2-[(2'-cyanobiphenyl-4-yl)methyl]-2-heptenoate

: 1239911-41-1
4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1.25 h / 20 °C

1.2: 12 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

3.1: potassium carbonate / acetonitrile / 65 °C

4.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 90 °C

With hydroxylamine hydrochloride; hydrogen; trimethylaluminum; sodium hydrogencarbonate; potassium carbonate; palladium 10% on activated carbon; In methanol; n-heptane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: C₂₂H₂₄N₂O₂

: 1239911-41-1
4'-{[6-butyl-3-(5-ethoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on-5-yl]methyl}-N'-hydroxybiphenyl-2-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 3 h / 20 - 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1.25 h / 20 °C

2.2: 12 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

4.1: potassium carbonate / acetonitrile / 65 °C

5.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 90 °C

With hydroxylamine hydrochloride; hydrogen; trimethylaluminum; sodium hydrogencarbonate; potassium carbonate; acetic acid; palladium 10% on activated carbon; In methanol; n-heptane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;