6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Base Information

• Chemical Name: 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS No.: 865756-07-6
• Molecular Formula: C₁₄H₉Cl₂N₃OS
• Molecular Weight: 338.217

Synonyms:6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Chemical Property of 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Chemical Property:

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Technology Process of 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

There total 9 articles about 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-(2,6-dichlorophenyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-amine (179343-52-3) → 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (865756-07-6)

Guidance literature:

With trifluoroacetic acid; sodium nitrite; at 20 ℃; for 2.75h; Cooling with ice;

Reference yield: 28.0%

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) + methyl 2-(2,6-dichlorophenyl)acetate (54551-83-6) → 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (865756-07-6)

Guidance literature:

With potassium fluoride on basic alumina; In N,N-dimethyl acetamide; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113252

Reference yield: 28.0%

→ 6-(2,6-dichlorophenyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (865756-07-6)

Guidance literature:

With aluminum oxide; potassium fluoride; In N,N-dimethyl acetamide; at 20 ℃; for 24h; Inert atmosphere;

upstream raw materials:

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

2-(2,6-dichlorophenyl)acetic acid

2,6-dichlorophenylacetonitrile

6-(2,6-dichlorophenyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-amine

Downstream raw materials:

trifluoro-methanesulfonic acid 6-(2,6-dichloro-phenyl)-2-methylsulfanyl-pyrido[2,3-d]pyrimidin-7-yl ester

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