770-31-0

Basic information

• Product Name: 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE
• Synonyms: 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE;4-Amino-2-(methylthio)pyrimidine-5-carboxaldehyde;2-METHYLTHIO 4-AMINO 5-FORMYL PYRIMIDINE;4-aMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde;4-AMino-2-(Methylthio)-5-pyriMidinecarboxaldehyde
• CAS NO: 770-31-0
• Molecular Formula: C₆H₇N₃OS
• Molecular Weight: 169.20428
• Product Categories: Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 770-31-0.mol
• Article Data: 42

Chemical Properties

• Melting Point: 183-184 °C
• Boiling Point: 379.7 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: /
• Density: 1.37
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.50±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE(770-31-0)
• EPA Substance Registry System: 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE(770-31-0)

Safety Data

• Hazardous Substances Data: 770-31-0(Hazardous Substances Data)

Usage

Uses

4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde can be used for the preparation of pyridopyrimidines and naphthyridines as inhibitors of Akt kinase for the treatment of cancer.

Upstream product

• 588-36-3 (4-amino-2-(methylthio)pyrimidin-5-yl)methanol 
• 770-30-9 4-amino-2-(methylthio)pyrimidine-5-carbonitrile 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 105161-35-1 4-amino-2-sulfanylpyrimidine-5-carbaldehyde 
• 776-53-4 ethyl 4-amino-2-methylmercaptopyrimidine-5-carboxylate 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 64-19-7 acetic acid 

Downstream Products

• 335653-68-4 3-(2-chlorophenyl)-7-methylthio-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 
• 251371-77-4 5-[(3,5-dimethoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-ylamine 
• 850451-67-1 6-(3-amino-2,6-dichloro-phenyl)-2-methylsulfanyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 850451-73-9 6-(5-amino-2-chloro-phenyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-ylamine 
• 867353-58-0 2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-ol 
• 211245-21-5 8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]-pyrimidin-7-one 

Relevant articles and documents

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A maleate, mesylate, benzene sulfonate, hydrochloride, phosphate, L-tartrate, L-malate, citrate, and fumarate of a compound represented by structural formula I, various crystal forms of each salt form, and a preparation method and application thereof.

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