ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

Base Information

Chemical Name:ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate
CAS No.:1313195-97-9
Molecular Formula:C₂₂H₁₇F₃N₂O₂S
Molecular Weight:430.45
Hs Code.:

Synonyms:ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

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Chemical Property of ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

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Technology Process of ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

There total 3 articles about ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 626-35-7
nitroacetic acid ethyl ester

: 1313195-96-8
2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-amine

: 122-51-0
orthoformic acid triethyl ester

: 1313195-97-9
ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

Guidance literature:: 2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-amine; orthoformic acid triethyl ester; With acetic acid; In ethanol; at 100 ℃; for 5h;

nitroacetic acid ethyl ester; In ethanol; at 100 ℃;

orthoformic acid triethyl ester; With hydrogen; palladium 10% on activated carbon; at 80 ℃;

Reference yield:

: 1207970-72-6
7-bromo-2-[3-(trifluoromethyl)benzyl]-1-benzothiophene

: 1313195-97-9
ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 24 h / 50 °C

3.1: acetic acid / ethanol / 5 h / 100 °C

3.2: 100 °C

3.3: 80 °C

With hydrogenchloride; water; acetic acid; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: C₂₉H₂₀F₃NS

: 1313195-97-9
ethyl 1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 24 h / 50 °C

2.1: acetic acid / ethanol / 5 h / 100 °C

2.2: 100 °C

2.3: 80 °C

With hydrogenchloride; water; acetic acid; In tetrahydrofuran; ethanol;