4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

Base Information

• Chemical Name: 4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole
• CAS No.: 718619-68-2
• Molecular Formula: C₂₁H₂₅F₃IN₅O₂
• Molecular Weight: 563.362
• Mol file: 718619-68-2.mol

Synonyms:4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

Chemical Property of 4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

There total 1 articles about 4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

N-amino{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carboxamide; 2-(4-iodo-2-fluoro-phenylamino)-3,4-difluoro-benzoic acid hydrazide (718619-66-0) + N,N-diethylpropylamine (4458-31-5) + 1,1'-carbonyldiimidazole (530-62-1) → 4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole (718619-68-2)

Guidance literature:

N,N-diethylpropylamine; 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 3h;

N-amino{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carboxamide; 2-(4-iodo-2-fluoro-phenylamino)-3,4-difluoro-benzoic acid hydrazide; In DMF (N,N-dimethyl-formamide); at 75 ℃; for 17h;

Reference yield: 59.6%

4'-N-N-diethylpropylamine-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole (718619-68-2) → N-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-N',N'-diethyl-propane-1,3-diamine (718617-99-3)

Guidance literature:

With tetrachloromethane; triethylamine; triphenylphosphine; In dichloromethane; at 20 - 45 ℃; for 4h;

upstream raw materials:

N-amino{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carboxamide; 2-(4-iodo-2-fluoro-phenylamino)-3,4-difluoro-benzoic acid hydrazide

N,N-diethylpropylamine

1,1'-carbonyldiimidazole

Downstream raw materials:

N-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-N',N'-diethyl-propane-1,3-diamine