7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine
CAS No.:737828-16-9
Molecular Formula:C₂₁H₁₅Cl₂N₃O
Molecular Weight:396.276
Hs Code.:

Synonyms:7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

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Chemical Property of 7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

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Technology Process of 7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

There total 9 articles about 7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 737827-68-8
7-Chloro-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

: 107-18-6
allyl alcohol

: 737828-16-9
7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

Guidance literature:: With sodium hydride;

Reference yield:

: 737827-54-2
7-Chloro-2-(2-chlorophenyl)-3-iodopyrazolo[1,5-a]pyrimidine

: 737828-16-9
7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 1.5 h / 87 °C

3.1: tetra(n-butyl)ammonium hydroxide; water / tetrahydrofuran / 60 °C

3.2: pH 4.5

4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 7 h / 20 - 100 °C

5.1: sodium hydride / 0 - 20 °C

With tetra(n-butyl)ammonium hydroxide; water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 737827-53-1
7-Chloro-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

: 737828-16-9
7-Allyloxy-3-(4-chlorophenyl)-2-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide / dichloromethane; chloroform / 0 - 20 °C

2.1: sodium hydride

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 1.5 h / 87 °C

4.1: tetra(n-butyl)ammonium hydroxide; water / tetrahydrofuran / 60 °C

4.2: pH 4.5

5.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 7 h / 20 - 100 °C

6.1: sodium hydride / 0 - 20 °C

With N-iodo-succinimide; tetra(n-butyl)ammonium hydroxide; water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; water; toluene;